HCLSIG/PharmaOntology/Meetings/2009-08-20 Conference Call

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Conference Details

  • Date of Call: Thursday August 20 2009
  • Time of Call: 12:00pm Eastern Daylight Time (EDT), 16:00 British Summer Time (BST)
  • Dial-In #: +1.617.761.6200 (Cambridge, MA)
  • Dial-In #: +33.4.89.06.34.99 (Nice, France)
  • Dial-In #: +44.117.370.6152 (Bristol, UK)
  • Participant Access Code: 42572 ("HCLS2").
  • IRC Channel: irc.w3.org port 6665 channel #HCLS2 (see W3C IRC page for details, or see Web IRC)
  • Mibbit instructions: go to http://www.mibbit.com/chat and click the server link. Enter irc.w3.org:6665 into that box, enter a nickname, and enter #HCLS2 for the channel
  • Duration: ~1h
  • Convener: Susie

Agenda

  • Review of Classes and Class Definitions

Minutes

Attendees: Colin, Susie, Chris, Bosse, Elgar, Michel, Joanne, Christi, Scott, Trish

<michel> colin: connection table: useful in chemiinformatics where a drug is being designed, but there is no such molecule exists yet

<michel> cost benefit analysis

<michel> trish: comes from use case

<michel> susie: should be split up at some point

<michel> colin: nothing particularly druggie about it

<michel> diagnosis

<michel> colin: diagnosis process vs diagnosis result

<michel> differential diagnosis: just part of normal practice

<michel> discipline: no

<michel> disease

<michel> important, should be obtained from disease ontology

<michel> disease symptoms

<JoanneLuciano> joanne (from above) - discipline shoud be specialty - to be added later

<JoanneLuciano> joanne (from above discussion) sometimes diagnosis is used for insurance reimbursement and isn't accurate with respect to the condition of the patient

<michel> dosage

<michel> susie: how often one should take drugs, and the amounts

<michel> joanne: guidelines

<michel> frequency, strength, dose (and units)

<michel> elgar: dosage vs dose? are they the same

<michel> dosage- the regime, dose is the amount

<michel> elgar: is dose in the clinical guidelines for treatment

<michel> susie: yes

<michel> elgar: dose and dosage are different, but important

<JoanneLuciano> Drug: Joanne: keep - but what identifer do we use? generic, commercial trademark name? how do we assure consistency in what's named here as the drug? is there an ID we can use?

<michel> drug

<michel> colin: lots of different meanings

<michel> colin: molecule, formulation, approved pharmaceutical product

<michel> bosse: many meanings, drugbank - uses brand drugs

<michel> elgar: compound, drug, pharmaceutical product, pharmaceutical brand

<michel> elgar: drug as an active pharmaceutical ingredient

<michel> colin: agrees with active pharmaceutical ingredient - avoids confusion

<michel> scott: variations of tylenol - different formulations

<michel> elgar: 4 terms required to capture the different meanings

<michel> elgar: keep drug - compound with therapeutic use

<michel> colin: keep active ingredient as opposed to giving drug this meaning

<Bosse> Paracetamol in DrugBank shows the challenge with many names: http://drugbank.ca/drugs/DB00316

<michel> colin: consider a primary ingredient

<michel> christi: active ingredient is a normal term in the vocabulary to describe the ingredients

<michel> *certain* ingredients

<michel> susie: active ingredient and drug should be kept

<mmarshal> active ingrdedient distinguishes from 'filler'

<JoanneLuciano> is there any confusion with the meaning of the term active ingredient?

<JoanneLuciano> Joanne: raised the concrete example to facilitate the discussion.

<michel> elgar: need to think more about it

<michel> drug interaction

<michel> colin: def doesn't talk about human

<michel> chris: brings the example where modification can occurs prior to administration (in the syringe)

<michel> michel: more of a catchall to capture the different kinds of drug-based interactions

<michel> drug metabolizing enzyme

<michel> genotyping/phenotyping important to determine dosage

<michel> susie: DME is only one of many components