HCLSIG/PharmaOntology/Meetings/2009-08-20 Conference Call
Conference Details
- Date of Call: Thursday August 20 2009
- Time of Call: 12:00pm Eastern Daylight Time (EDT), 16:00 British Summer Time (BST)
- Dial-In #: +1.617.761.6200 (Cambridge, MA)
- Dial-In #: +33.4.89.06.34.99 (Nice, France)
- Dial-In #: +44.117.370.6152 (Bristol, UK)
- Participant Access Code: 42572 ("HCLS2").
- IRC Channel: irc.w3.org port 6665 channel #HCLS2 (see W3C IRC page for details, or see Web IRC)
- Mibbit instructions: go to http://www.mibbit.com/chat and click the server link. Enter irc.w3.org:6665 into that box, enter a nickname, and enter #HCLS2 for the channel
- Duration: ~1h
- Convener: Susie
Agenda
- Review of Classes and Class Definitions
Minutes
Attendees: Colin, Susie, Chris, Bosse, Elgar, Michel, Joanne, Christi, Scott, Trish
<michel> colin: connection table: useful in chemiinformatics where a drug is being designed, but there is no such molecule exists yet
<michel> cost benefit analysis
<michel> trish: comes from use case
<michel> susie: should be split up at some point
<michel> colin: nothing particularly druggie about it
<michel> diagnosis
<michel> colin: diagnosis process vs diagnosis result
<michel> differential diagnosis: just part of normal practice
<michel> discipline: no
<michel> disease
<michel> important, should be obtained from disease ontology
<michel> disease symptoms
<JoanneLuciano> joanne (from above) - discipline shoud be specialty - to be added later
<JoanneLuciano> joanne (from above discussion) sometimes diagnosis is used for insurance reimbursement and isn't accurate with respect to the condition of the patient
<michel> dosage
<michel> susie: how often one should take drugs, and the amounts
<michel> joanne: guidelines
<michel> frequency, strength, dose (and units)
<michel> elgar: dosage vs dose? are they the same
<michel> dosage- the regime, dose is the amount
<michel> elgar: is dose in the clinical guidelines for treatment
<michel> susie: yes
<michel> elgar: dose and dosage are different, but important
<JoanneLuciano> Drug: Joanne: keep - but what identifer do we use? generic, commercial trademark name? how do we assure consistency in what's named here as the drug? is there an ID we can use?
<michel> drug
<michel> colin: lots of different meanings
<michel> colin: molecule, formulation, approved pharmaceutical product
<michel> bosse: many meanings, drugbank - uses brand drugs
<michel> elgar: compound, drug, pharmaceutical product, pharmaceutical brand
<michel> elgar: drug as an active pharmaceutical ingredient
<michel> colin: agrees with active pharmaceutical ingredient - avoids confusion
<michel> scott: variations of tylenol - different formulations
<michel> elgar: 4 terms required to capture the different meanings
<michel> elgar: keep drug - compound with therapeutic use
<michel> colin: keep active ingredient as opposed to giving drug this meaning
<Bosse> Paracetamol in DrugBank shows the challenge with many names: http://drugbank.ca/drugs/DB00316
<michel> colin: consider a primary ingredient
<michel> christi: active ingredient is a normal term in the vocabulary to describe the ingredients
<michel> *certain* ingredients
<michel> susie: active ingredient and drug should be kept
<mmarshal> active ingrdedient distinguishes from 'filler'
<JoanneLuciano> is there any confusion with the meaning of the term active ingredient?
<JoanneLuciano> Joanne: raised the concrete example to facilitate the discussion.
<michel> elgar: need to think more about it
<michel> drug interaction
<michel> colin: def doesn't talk about human
<michel> chris: brings the example where modification can occurs prior to administration (in the syringe)
<michel> michel: more of a catchall to capture the different kinds of drug-based interactions
<michel> drug metabolizing enzyme
<michel> genotyping/phenotyping important to determine dosage
<michel> susie: DME is only one of many components