• HCLSIG BioRDF Subgroup
• Data

Data Sources in RDF/OWL

• Ontology / Dataset	Ontology type	Content
  Annotea Bookmark File	RDF / Instance style	bibliographic information
  Antibodies	?
  BAMS	OWL DL / Class style	Neuroanatomy, neuron classification and description
  BIND in BioPAX	OWL DL / Instance style	Molecular interactions
  Biocyc, Reactome, KEGG	?	Molecular interactions, bibliographic information
  Biocyc, Reactome, KEGG, INOH in BioPAX	OWL DL / Instance style	Molecular interactions, bibliographic information
  Reactome in bio-zen	OWL DL / Instance style	Molecular interactions, bibliographic information
  Entrez Gene	OWL DL	sequence information, bibliographic information
  /Enzymes (a subset)	RDF / Instance style
  GO (a subset)	RDF / Instance style
  HIVSDB
  /IntAct (a subset)	RDF / Instance style	Molecular interactions
  /KEGG (a subset)	RDF / Instance style
  MeSH	RDF / Instance style	subject headings
  MGED	OWL DL	terminology (mircoarrays)
  Neurocommons data (not yet officially released)	OWL DL / Instance style	molecular interactions, bibliographic information
  /OMIM (a subset)	RDF / Instance style
  PDSP Ki(at bottom of page)	OWL DL / Instance style	Molecular interactions, bibliographic information
  /Pubmed (a subset)	RDF / Instance style	bibliographic information
  SwissProt Keywords (a subset)
  SenseLab (RDF version)	RDF / Instance style	Neuroanatomy, Neuron classification and description, bibliographic information, hypotheses
  SenseLab (OWL version)	OWL DL / Class style	Neuroanatomy, Neuron classification and description, bibliographic information, hypotheses
  SMID	?
  SWAN publication and hypothesis data (new OWL version)	OWL DL / Instance style	hypotheses, bibliographic information
  /Taxonomy (a subset)
  UniProt	RDF / Instance style	sequence information

The following ontologies from the OBO repository are not listed in the table, but are of potential importance: MeSH (note that current OBO version has flaws), GO, Chebi, Celltype, Entrez Taxonomy. They can be downloaded as 'RDF / Instance style' or 'OWL / Class style' from http://www.berkeleybop.org/ontologies/

Mappings

• Ontology / Dataset	Ontology type	Content
  Senselab / OBI / Birnlex / BAMS / BFO mapping (under construction)	OWL / Class style
  /Enzymes 2 KEGG (a subset)	RDF / Instance style
  GO 2 Enzymes (a subset)	RDF / Instance style
  /GO 2 Keywords (a subset)	RDF / Instance style
  /GO 2 OMIM (a subset)	RDF / Instance style
  /GO 2 Probe (a subset)	RDF / Instance style
  GO 2 Protein (a subset)	RDF / Instance style
  GO 2 PubMed (a subset)	RDF / Instance style
  /Keyword 2 Protein (a subset)	RDF / Instance style
  /Protein 2 IntAct (a subset)	RDF / Instance style

Mappings and their benefits should be described on the Mappings of neuroscience ontologies and their advantages wiki page.

Description of these tables

Ontology types: Describes whether the ontology is pure RDF (without or mostly without OWL constructs), OWL DL (including ontologies that are actually OWL lite and ontologies that are supposed to be OWL DL but classify as OWL Full because of some errors in ontology design) or OWL Full (ontologies that are intended to be OWL Full). Furthermore, we distinguish between 'Class style' (ontologies that mostly rely on classes and property restrictions for the expression of data and information) and 'Instance style' (ontologies that have a smaller set of classes that act as a 'schema', but mostly rely on instances for the expression of data and information).

Table Layout from 2007-04-11 f2f

This is copied from the whiteboard. I hope it's close.

NeuronDB

• protein (channels/receptors)
• neurotransmitters
• neuroanatomy
• cell
• compartments
• currents

BAMS

• protein -> NeuronDB.protein

• neuroanatomy
• cells

• metabolites -> NeuronDB.channels

• pubmed ID

NC Annotations

• {links genes (and some processes) to pubmed (articles?)} {human (by interpretation)}
• genes or gene products (proteins)
• processes
• cells (maybe)
• pubmed papers

Allen Brain Atlas (mouse)

• genes
• brain images

• gross anatomy -> neuroanatomy -> neuroanatomy

Homologene

• genes {pairs}
• species {pairs}
• orthologies
• proofs

SWAN

• pubmed ID
• hypothesis statements (discourse ontology)
• research questions (discourse ontology)
• evidence
• genes

Entrez Gene (human/mouse/rat)

• gene
• protein
• GO terms {this protien catalyzes alcohol to alkalide}
• pubmed ID
• interaction (genes/protien)
• chromosome
• chromosome location

GO (human/mouse/rat)

• molecular function
• cell component
• biological process
• annotation gene (tbd)
• pubmed ID

Mammalian Phenotype (human/mouse/rat)

• genes
• phenotypes
• disease
• pubmed ID (J#)

PDSPki (biopax)

• proteins (receptors)
• chemicals
• neurotransmitter

BrainPharm (vertebrates) {pathological processes}

• drug
• drug effect
• pathological agent
• pathological effect
• receptors
• channels
• cell type
• pubmed ID
• disease

AlzGene

• gene
• polymorphism
• population
• associated Alz diagnosis

Antibodies

• genes
• antibodies

PubChem

• compound name
• compound structure
• compound properties
• (mesh terms)

MESH

• drugs
• anatomy
• phenotypes
• compounds
• chemicals
• pubmed ID
• pubchem

Reactome (human+) (biopax)

• genes/proteins
• interactions
• cellular location (component)
• processes (GO links)